9 Sept 2019

RNAcentral release 13

We are pleased to announce that a new RNAcentral release is now available. Version 13 includes 7 million secondary structure diagrams for >2,000 Rfam families as well as new data from three Ensembl divisions (Fungi, Protists, and Metazoa). Read on for more details.

Over 7 million RNA secondary structure diagrams

Starting with release 12, RNAcentral has included secondary structure (2D) diagrams for small subunit and 5S rRNAs. The structures are visualised using family-specific templates so that related RNAs look in a similar way.
Now we expanded the auto-traveler pipeline to use Rfam consensus secondary structure diagrams as templates so that RNA sequences from >2,000 Rfam families can be displayed in consistent orientations. One can visually compare 2D structures of sequences from the same family. For example, the following diagram shows the human and mouse SCARNA13 drawn in the same orientation using the RF00231 consensus as a template:

The colours tell whether the sequence is identical to the Rfam consensus (shown in black) or is different (shown in green).

View 2Ds in search results and sequence reports

The new 2D diagrams are now shown in text search results:

and sequence report pages where you can explore the diagram by zooming and panning. We invite your feedback about individual 2D structures so please click on the Is this diagram useful? button and let us know what you think.

Work is underway on generating 2D diagrams for large subunit rRNAs and the remaining Rfam families. For details on the new data, see the help centre or browse the new structures in RNAcentral.

Data updates

The following database have also been updated:

  • ENA (140)
  • Ensembl (97) as well as newly imported Ensembl Protists, Fungi, and Metazoa
  • FlyBase (FB2019_04)
  • HGNC
  • PDB
  • RefSeq
  • TAIR
  • PomBase
  • WormBase (WS270)

Get in touch

As always, all data are freely available on the RNAcentral website, via the API, and in the FTP archive. The next release is tentatively scheduled for December 2019. In the meantime, if you have any feedback, please get in touch by email, on Twitter, or by submitting an issue on GitHub. We look forward to hearing from you!